Call Now
(415) 236-9991
Edit Search
You must provide a location
Check In - Check Out
Rooms and Guests
2 Adults, 1 Room
Rooms
1
Adults
2
Children
0
Rooms must be less than number of adults
Children's ages must be provided
36 photos

Holiday Inn Express And Suites Downtown Buffalo Ex Comfort Suites

601 Main St, Buffalo, NY

Check In
06/28/2026
Check Out
06/29/2026
Rooms
1
1
2
3
4
5
6
7
8
9
Adults
2
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
Children
0
0
1
2
3
4
5
6
7
8
Enter children's ages (infant to 17 years):
Rooms must be less than number of adults
Children's ages must be provided
FIND ROOMS
Check In Date
Check Out Date

Have questions? We're here to help!

(415) 236-9991
Reservations Portal is an independent travel network. Learn More
Reasons to book with ReservationsPortal

As an independent travel network with access to over 100,000 hotels worldwide, we bring you the same great deals you'd find with major travel agencies or booking directly with hotels. By sourcing the best rates from top suppliers, we make it easy to find and book your ideal room. Our platform also features a seamless booking engine for all devices, a strong commitment to privacy, and exceptional customer support—delivering the complete Reservations Portal experience.

Room Options

Best Value!

Standard

View amenities and details
Check Rates
Room Details
Standard
Room Facilities
Air Conditioning Individually Controlled In Room
Alarm Clock
Bathtub Seat
Cleaning Products
Desk/Workspace
Microwave Oven
Refrigerator
Television

1 Bedroom, Suite, Accessible

View amenities and details
Check Rates
Room Details
1 Bedroom, Suite, Accessible
Room Facilities
Accessible Bathtub
Air Conditioning Individually Controlled In Room
Alarm Clock
Bathtub Only
Bathtub Seat
Cleaning Products
Desk/Workspace
Microwave Oven
Refrigerator
Television
Wheel Chair Accessible

1 Bedroom, Suite

View amenities and details
Check Rates
Room Details
1 Bedroom, Suite
Room Facilities
Air Conditioning Individually Controlled In Room
Alarm Clock
Bathtub Seat
Cleaning Products
Desk/Workspace
Microwave Oven
Refrigerator
Television

Suite, Accessible

Check Rates
Room Details
Suite, Accessible

1 Bedroom, Suite, King Bed

View amenities and details
Check Rates
Room Details
1 Bedroom, Suite, King Bed
Room Facilities
Air Conditioning
Alarm Clock
Am/Fm Radio
Cleaning Products
Clothes Rack
Desk/Workspace
Down/Feather Pillows
Hair Dryer
In Room Safe
Iron/Ironing Board
Key Access
Key Card Access
Microwave Oven
Non-Feather Pillow
Refrigerator
Safety Box
Shampoo
Slippers
Tea And Coffee Making Facility
Telephone
Television
Toilet Paper
Towels And Linen
Wake-Up Service

Suite, King Bed

Check Rates
Room Details
Suite, King Bed

1 Bedroom, Suite, Queen Bed, Accessible

Check Rates
Room Details
1 Bedroom, Suite, Queen Bed, Accessible

1 Bedroom, Queen Bed, Accessible

View amenities and details
Check Rates
Room Details
1 Bedroom, Queen Bed, Accessible
Room Facilities
Air Conditioning
Alarm Clock
Am/Fm Radio
Cleaning Products
Clothes Rack
Desk/Workspace
Down/Feather Pillows
Hair Dryer
In Room Safe
Iron/Ironing Board
Key Access
Key Card Access
Microwave Oven
Non-Feather Pillow
Refrigerator
Safety Box
Shampoo
Shower Chair
Slippers
Tea And Coffee Making Facility
Telephone
Television
Toilet Paper
Towels And Linen
Wake-Up Service

Suite, Queen Bed, Accessible

View amenities and details
Check Rates
Room Details
Suite, Queen Bed, Accessible
Room Facilities
Air Conditioning
Alarm Clock
Am/Fm Radio
Cleaning Products
Clothes Rack
Desk/Workspace
Down/Feather Pillows
Hair Dryer
In Room Safe
Iron/Ironing Board
Key Access
Key Card Access
Microwave Oven
Non-Feather Pillow
Refrigerator
Safety Box
Shampoo
Shower Chair
Slippers
Tea And Coffee Making Facility
Telephone
Television
Toilet Paper
Towels And Linen
Wake-Up Service
Cancellation Rules
Limited Availability

Inventory is based on real-time data provided by our supply partners. Availability is strictly limited to the allotment provided to us and is subject to change.

24-Hour Free Cancellation

Holiday Inn Express And Suites Downtown Buffalo Ex Comfort Suites Amenities

Dry cleaning/laundry service
Wheelchair accessible (may have limitations)
Casino nearby
Vegetarian breakfast available
Eco-friendly cleaning products used
Wheelchair-accessible van parking
Wheelchair-accessible path to elevator
Wheelchair-accessible fitness center
Free WiFi
Wheelchair accessible parking
Free buffet breakfast
Comprehensive food waste policy
Off-street parking
LED light bulbs
Wheelchair-accessible on-site restaurant
Luggage storage
Free breakfast
Business center
24-hour front desk
Wheelchair-accessible meeting spaces/business center
Golfing nearby
Smoke-free property
Safe-deposit box at front desk
Laundry facilities
Elevator
Fitness facilities
Wheelchair accessible path of travel

Holiday Inn Express And Suites Downtown Buffalo Ex Comfort Suites Hotel Details

We welcome you to stay at our Holiday Inn Express &Suites Buffalo, located in the heart of downtown near Roswell Park, John R. Oishei Children's Hospital, Buffalo General Hospital, Convention Center and Canalside. Hotel parking is available nearby at additional charge in parking garage. Enjoy being nestled in the heart of the Theatre District, where you can experience a grand performance at Shea's Performing Arts Center or the Irish Classical Theatre. Take in a concert at the Town Ballroom or TRALF located within the same block or hop on the above ground trolley train to the Key Bank Center. The Seneca Buffalo Creek Casino offers a free shuttle to and from the casino. Explore &More - Ralph C. Wilson Jr. Children's Museum and the Naval Park are also just a few blocks away. The city is also packed with events and festivals at Canalside and Sahlen's Field. Admire contemporary art at the Albright-Knox Art Gallery or discover Frank Lloyd Wright's stunning residencies nearby and marvel at the Darwin Martin House. Don't forget to make the 20 mile trip to one of the Nation's North American Wonders of the World - Niagara Falls!For those traveling on business we are in close proximity to M&T Bank, Buffalo Niagara Medical Campus, and New Era Cap. You will appreciate our 24-hour business center and fitness center. Also located adjacent to the hotel is a TGI Friday’s restaurant.
Holiday Inn Express And Suites Downtown Buffalo Ex Comfort Suites
601 Main St, Buffalo, NY
Choose your dates to book today's available rooms and dates
Check In
06/28/2026
Check Out
06/29/2026
Rooms
1
Adults
2
Children
0
Rooms must be less than number of adults
Children's ages must be provided
FIND ROOMS
Check In Date
Check Out Date
Confirm Your Dates
You're about to search for rooms from to . Are these the correct dates for your stay?
Yes, find rooms Change dates

Securing your special rate...

SECURE ENCRYPTION ACTIVE
CHECK-IN
CHECK-OUT
RATE NOT GUARANTEED UNTIL BOOKED