VegasVacay is an independent travel network.
Edit Search
You must provide a location
Check In - Check Out
11/10/2026 - 11/11/2026
Rooms and Guests
2 Adults, 1 Room
Rooms
1
Adults
2
Children
0
Rooms must be less than number of adults
Children's ages must be provided
17 photos

Holiday Inn Express & Suites Hannibal - Medical Center

120 Shinn Lane, Hannibal, MO

Have questions? We're here to help!

(888) 450-6644
Check In - Check Out
Rooms
1
1
2
3
4
5
6
7
8
9
Adults
2
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
Children
0
0
1
2
3
4
5
6
7
8
Enter children's ages (infant to 17 years):
Rooms must be less than number of adults
Children's ages must be provided
Find Rooms
Reservations Portal is an independent travel network. Learn More
Reasons to book with ReservationsPortal

As an independent travel network with access to over 100,000 hotels worldwide, we bring you the same great deals you'd find with major travel agencies or booking directly with hotels. By sourcing the best rates from top suppliers, we make it easy to find and book your ideal room. Our platform also features a seamless booking engine for all devices, a strong commitment to privacy, and exceptional customer support—delivering the complete Reservations Portal experience.

Room Options

Select your dates to view available rooms and rates.

Best Value!

Standard, King Bed, Accessible

Standard

Standard, King Bed

Standard, 2 Queen Beds, Accessible

Standard, 2 Queen Beds

Suite, King Bed, Living Area

Suite, King Bed, Accessible

Suite, 2 Queen Beds, Accessible

Suite, 2 Queen Beds, Living Area

Limited Availability

Inventory is based on real-time data provided by our supply partners. Availability is strictly limited to the allotment provided to us and is subject to change.

24-Hour Free Cancellation

Holiday Inn Express & Suites Hannibal - Medical Center Amenities

Wheelchair accessible (may have limitations)
Wheelchair-accessible van parking
Assistive listening devices in meeting rooms
Number of meeting rooms - 1
Pool hoist on site
Wheelchair-accessible fitness center
Wheelchair-accessible pool
Free WiFi
Number of indoor pools - 1
Garden
Wheelchair accessible parking
Free buffet breakfast
Wheelchair-accessible lounge
Free breakfast
Business center
24-hour front desk
Wheelchair-accessible meeting spaces/business center
Smoke-free property
Coffee/tea in common areas
Laundry facilities
Free self parking
Elevator
Fitness facilities
Wheelchair accessible path of travel

Policies

Check-in: 3:00 PM, minimum check-in age 21. Check-out: 11:00 AM

Holiday Inn Express & Suites Hannibal - Medical Center Hotel Details

Welcome to the Holiday Inn Express &Suites in Hannibal, MO. We are conveniently located off Interstate 36 at the Shinn Lane exit making it a convenient choice for both business and leisure travelers. We are just walking distance from the Hannibal Regional Hospital, Hannibal Clinic, the James E Cary Cancer Center, and an array of dining options. The Holiday Inn Express &Suites is also in close proximity to the following major companies, BASF Corporation, Continental Cement, General Mills, Spartan LMP, and Watlow to name just a few. Hannibal's Historic Downtown is a short car ride away. Some of the local attractions are the Mark Twain Boyhood Home and Museums, the Mark Twain Cave, Mark Twain Riverboat, Hannibal Trolley Tours, Rockcliffe Mansion, and Haunted Hannibal Ghost Tours. Whether in town for business or pleasure, our hotel offers modern comfort with a feeling of home. Our nicely appointed rooms include high-speed wireless Internet, 42 inch flat screen TVs, microwaves and refrigerators. The hotel is also equipped with a business center, guest laundry, meeting space and deluxe suites are available. After your busy day, feel free to take a dip in the indoor heated pool or enjoy your workout in the fitness center. You can fill up at the Express Start Breakfast Bar with a delicious array of hot and cold favorites. Make your reservations to Stay Smart at our hotel.
Holiday Inn Express & Suites Hannibal - Medical Center
120 Shinn Lane, Hannibal, MO
Choose your dates to see available rooms and rates
Check In
Check Out
Rooms
1
Adults
2
Children
0
Rooms must be less than number of adults
Children's ages must be provided
FIND ROOMS
Confirm Your Dates
You're about to search for rooms from to . Are these the correct dates for your stay?
Yes, find rooms Change dates

Check-in
-
Check-out